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2 ROS are generated in cells routinely as by-products of oxygen metabolism

In parental (wild-type mtDNA) cells, 5FU drives significant increases in mitochondrial mass

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Baltaci, Davut, et al

The 21st chromosome contains SOD1 gene, which encodes the enzyme Cu-Zn superoxide dismutase (Cu-Zn SOD), responsible for the conversion of O 2 to H 2 O 2 in the cytosol