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J Clin Endocrinol Metab (2021) 106(1):e11e9

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Heres what you can realistically expect: Semaglutide Results Timeline Weeks 1-4: Initial appetite suppression begins Months 2-3: Noticeable weight loss (3-5% of body weight) Months 4-6: Significant changes (8-12% weight loss) Month 12: Peak results (15-17% average weight loss) Tirzepatide Timeline Weeks 1-4: Appetite changes and initial weight loss begin Months 2-3: More pronounced effects (4-7% weight loss) Months 4-6: Substantial changes (10-15% weight loss) Month 12: Maximum benefits (16-22% average weight loss) Remember, these timelines represent averages

This increase in effectiveness is explained by a new pharmacological mechanism: each generation adds a target receptor

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This can reduce side effects while maintaining or improving efficacy a principle well-established in pharmacology