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Integration of local IGF-I/IGF-IR signaling with systemic hormones Integration with GH Although it is well established that GH stimulates hepatic gene expression to make and supply IGF-I to the circulation, recent studies suggest that changes in circulating IGF-I levels may be an indicator of GH status, but may not be directly involved in controlling local functions in non-hepatic tissues, including bone (68)

Increasing evidence indicates that elevated GSH level may contribute to chemotherapy resistance

GSH prevents LOsG-induced pancreatic fibrosis via the TGF/SMAD pathway in vivo Considering the crucial role of TGF-1 in organ fibrosis, we examined whether LOsG contributed to TGF-1 expression by detecting TGF-1 protein levels in pancreatic tissues using western blotting

10.1161/CIRCULATIONAHA.108.815043 129 WangJ.ShiJ.WeiJ.WangJ.GaoK.LiX.et al (2017)

The muscle recovery benefits of IGF-1 are particularly significant for athletes who experience regular tissue wear and tear

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