These can worsen GLP-1 side effects like nausea, reflux, and bloating
Drugs 32 , 9971001 (2023)
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It primarily cleaves peptides at the N-terminal side of aromatic or hydrophobic amino acids and is estimated to contribute by up to 50% to GLP-1 degradation
A modified version of exenatide was developed by adding lysine residues to the C-terminal (lixisenatide)