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Building upon previous attempts to characterize essential cell populations, we elaborate on neuronal populations and pathways that engage with GLP-1RAs and, thus, may explain overall pharmacologic efficacy

The next table organizes these benefits by organ system, showing how widespread their impact is

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Safety Profile (Phase 2) The most common adverse events were gastrointestinal and consistent with the incretin drug class: - Nausea - Diarrhea - Vomiting - Constipation - Decreased appetite These GI events were dose-related, mostly mild to moderate, and partially mitigated by starting at a lower initial dose (2 mg vs