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Adding more pharmacological agents may not be necessary and could increase health risks
Utilizing these two cell lines, the in vitro co-culture system was established within a transwell chamber, which allowed the two layers of cells to interact with each other, to investigate the interactions between C3G, GLP-1 secretion, and insulin release
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The upcoming Phase I/II clinical trial will test the safety and preliminary efficacy of RJVA-001, a gene therapy designed to locally deliver GLP-1 receptor agonist drugs with the goal of reducing the side effects associated with oral administration
Steady state is reached after 4 to 5 weeks at each dose level
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