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It is currently unclear if the resistance to GLP-1 is primarily due to impaired receptor expression, reduced signaling in the gut-brain axis and/or intestinal dysbiosis
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N Engl J Med 392(5):427437 Pratley RE, Tuttle KR, Rossing P, Rasmussen S, Perkovic V, Nielsen OW et al (2024) Effects of semaglutide on heart failure outcomes in diabetes and chronic kidney disease in the FLOW trial