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10.1016/j.sleep.2023.09.026 11 HasegawaE.MiyasakaA.SakuraiK.CherasseY.LiY.SakuraiT

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Aging (Reduced Synthesis Capacity) As you age, production of glutathione declines due to: Reduced activity of gamma-glutamylcysteine ligase (GCL) , the rate-limiting enzyme in glutathione synthesis Decreased cellular energy (ATP) to fuel glutathione recycling Lower levels of precursor amino acids (especially cysteine and glycine) Studies show glutathione levels drop 10-15% per decade after age 40 [3]

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Glutathione has strong clinical rationale for melanin regulation, yet conventional oral and topical forms lose most of their activity before reaching the melanocyte layer where brightening actually occurs

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