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368 Since GLP-1R is expressed in thyroid C cells and GLP-1 directly stimulates the secretion of calcitonin, which is a potent inhibitor of bone resorption in osteoclasts, GLP-1 may contribute to the nutrient-mediated reduction in bone resorption

Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries

Note that it's important to make sure your weight loss is done in a healthy way

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Key Ingredients & Benefits L-Arginine (3 gm) Enhances nitric oxide production to improve blood flow

Treating obesity through diet and exercise is linked with better outcomes, at least according to a study published in 2012 in the British Medical Journal