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Neurotrophins such as BDNF and NGF play central roles in synaptic plasticity, neuronal survival, and network organization, and their dysregulation may represent a more proximal mechanism underlying behavioral impairments

Eur J Drug Metab Pharmacokinet 1991, 3648 Frolich J, Seccombe DW, Hahn P, et al

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In this context, we also demonstrated that the disruption of the cellular redox buffer, controlled by GSH, increases not only the oxidative stress (Filomeni et al., 2005a), but also the endogenous physiological flux of NO in neuronal cells ( S -nitrosylation, and DNA strand breaks in neuronal cells

574 As a negative regulator in cardiac hypertrophy, SIRT3 protects the heart by inhibiting intracellular ROS

Neuroscience 284, 900911 (2015)