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Emerging evidence suggests that ACs play a pivotal role in immune-metabolic pathways, linking lipid metabolism to mitochondrial function, with inadequate energy production contributing to metabolic stress, inflammation, and insulin resistance, all of which tied to depression pathophysiology [15]

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Across compounds, the variability in dosing regimens, developmental timing, behavioral assays, and redox endpoints impose interpretive caution and require harmonization for future translational work

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