In particular, [1- 13 C]DHA, a 13 C enriched version of dehydroascorbic acid, has been studied with hyperpolarized (HP) 13 C magnetic resonance (MR) in preclinical models of cancer, diabetes, acute kidney injury, and fatty liver disease 15,16,17,18,19,20
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The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1
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65,66,67 MTHFD2 is postulated to be the main switch that produces additional one-carbon units in mitochondria to enable rapid growth