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These compounds reduced the uptake of drug-coupled PLGs (Fig
The cumulative effect of these factors - protection from digestive degradation, improved cellular uptake, sustained release, and reduced first-pass metabolism - is significantly enhanced bioavailability
In one study, the administration of IGF-1 to rats with diabetic cardiomyopathy produced several beneficial effects, including a reduction in myocardial apoptosis, oxidative stress, inflammation, interstitial fibrosis, and metabolic irregularities
Free Rad Biol Med 4 :185198
10.3389/fcell.2020.590226 31 ChenY.ZhaoY.MiaoC.YangL.WangR.ChenB.et al (2022)
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