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(2022) J Med Chem 65 : 8208-8226 PubMed: 35647711 Search on PubMedSearch on PubMed Central DOI: Primary Citation Related Structures: 7S15 PubMed Abstract: Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited because they require injection

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High-fat diets increase hepatic MANF release, activating the p38-MAPK pathway and promoting adipose tissue browning [280]

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By the time someone reaches their maintenance dose, many of the early GI issues have resolved or become much more manageable

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