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As a result, fat loss occurs throughout the body, and the areas that shrink first depend on tissue biology and blood flow, not on any drug choice
doi:10.1016/S1386-6532(02)00128-2 Maes M, Bonaccorso S
They are not interchangeable, especially not with IGF-1 LR3
Gastroparesis and severe GI motility problems on tirzepatide In December 2025, the FDA updated both the Mounjaro and Zepbound prescribing information to add a specific warning about severe gastroparesis (Section 5.6): tirzepatide is not recommended for people with pre-existing severe gastroparesis
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