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doi:10.1016/j.immuni.2012.06.020

Native IGF-1 binds IGFBP-3, the dominant carrier protein in circulation, with a dissociation constant in the low nanomolar range (Kd approximately 0.1 to 1 nM in most published binding assays)

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A B12 deficiency can result in fatigue, weakness, memory problems, and even more severe health issues such as anaemia or neurological damage if left untreated

This has been demonstrated in lung cancer mouse models, chromophobe renal cell carcinoma and colorectal cancer

Persistent very high levels (for example, sustained above 3 SDS in clinical context) may need clinician review, dose adjustment, or stopping