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Pharmacology (Proof of Mechanism) Context of Use: Confirm that the molecule engages the target and produces the expected pharmacological effect in a living system

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Liu JS, Dong C, Vo AX, Dickmeyer LJ, Leung CL, Huang RA, Kielb SJ, Mukherjee S

Malpractice insurers might refuse coverage if a claim arises from an activity that is unlawful or outside the scope of standard practice