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Goodman states
Cardiolipin can be oxidized by ROS or by the cardiolipincytochrome c complex ( c from cardiolipin might also be triggered by increased cytosolic calcium, which weakens the electrostatic interaction between cytochrome c and cardiolipin and further generates ROS via MPT
Other genes involved in muscle anabolism such as androgen receptor, insulin receptor, IGF-1 and its receptor were evaluated but were not affected by the supplementation (data not shown)
Weight loss continues through 72-88 weeks in clinical trials, so premature discontinuation prevents accurate assessment of treatment response
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