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Patients with coexisting diabetes or obesity and Crohn's disease require careful coordination between specialists, as GLP-1 agonists' gastrointestinal side effects overlap significantly with IBD symptoms, potentially complicating disease monitoring and management
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In comparison, lizard GLP-1 itself shares an 83% sequence identity to human GLP-1 (84) [ Figure 2 ]
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10 To obtain dual activities, which seems to contribute the most in its illustrious clinical effects, tirzepatide not only fuses amino acid residue mainly from GLP-1 and GIP, but also uses some distinctive residues
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