is tirzepatide more effective than semaglutide caused roughly half as many patients to stop treatment because of gastrointestinal side effects as semaglutide. In the first major head-to-head obesity trial, GI side effects caused treatment discontinuation in: Tirzepatide Tirzepatide as Compared with Semaglutide

A few practical notes about this chart

Growth hormone peptides like sermorelin or ipamorelin work by stimulating your pituitary gland

Tesamorelin plus tirzepatide Tirzepatide dual-agonist approach (GLP-1 plus GIP) sits between semaglutide and retatrutide in both efficacy and novelty

7 Wegovy 7.2 mg (MHRA-approved January 2026): 18.7% on average over 72 weeks, rising to 20.7% in fully adherent participants, closer to Mounjaros results, though still below retatrutide

Theyve lost a lot of weight, they are super-motivated to keep it off, and they are willing to spend money on products that work for them, she says

Their effects on GLP-1 secretion itself appear to be modest and variable