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IGF-1 suppresses pro-inflammatory cytokine production (notably TNF-alpha and IL-6) through PI3K/Akt signaling

Month 4+ Optimization You land at your effective dose and the focus shifts to sustainability protein intake, resistance training, sleep, and protecting lean mass while losing fat

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It can be uncomfortable, especially at first

If three or more cortisol indicators persist (wired at night and tired in the morning, 2 to 3 pm crash, evening cravings without hunger, disrupted sleep, stalled loss despite adherence), consider diurnal salivary cortisol testing (section 9)