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If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution

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It is used to treat or prevent vitamin B12 deficiency caused by conditions such as pernicious anemia, low dietary intake, certain gastrointestinal disorders, or surgeries that reduce absorption

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Niacinamide at 5 percent topical concentration has two well-replicated controlled trials by Procter and Gamble researchers establishing the cosmetic case

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