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Polymorphisms in GLP-1 receptor genes, incretin pathway enzymes, and appetite regulation circuits influence individual response

Controlled negative result: topical GHK-Cu gel on irradiated rat dorsal flaps showed no difference versus control in flap ischemia, vessel number/area or VEGF expression counter-evidence that the copper-tripeptide class is not uniformly effective even topically

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Preclinical studies suggest possible effects on gut integrity, inflammation, blood vessels, and neurological signaling