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In contrast, the key lipogenic and fibrogenic genes that are suppressed by Chac1 overexpressioninduced hepatic GSH depletion, including Srebf1 , Scd , Dgat2 , Spp1 , Col1a1 , and Sox9 , were upregulated during disease progression (Figure 6, E and F)

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Rduction de linflammation et du stress oxydatif : Lactivation de la mlanocortine par le Melanotan II conduit la suppression des cytokines pro-inflammatoires telles que le TNF- et lIL-1, ainsi qu une activit accrue des enzymes antioxydantes