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Careful Administration (Use with Caution) 13.1 Patients with Renal Impairment It's really important to keep a close eye on how well the kidneys are working, especially in patients who are losing a lot of fluid through their digestive system

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While these gastrointestinal symptoms are generally mild to moderate and tend to diminish over time as the body adjusts to treatment, they can occasionally be severe enough to warrant dose adjustment or discontinuation