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Understanding the math behind the chart is better
The polymer P3 was synthesized by condensation polymerization using 2,2-(propane-2,2-diylbis(sulfanediyl))bis(ethan-1-ol), 1H,1H,10H,10H-perfluoro-1,10-decanediol, and 1,2,4,5-cyclohexanetetracarboxylic acid dianhydride (Supplementary Fig
The triple agonist already maximally activated the relevant pathway
In the end biology always wins out over willpower, so with even the best intentions, the weight is regained
Subtle dynamics allows the C-terminal of the ligand to access the ECD binding site, and the binding of the ligand triggers further dissociation between the ECD and TMD, allowing the N-terminal to enter the orthosteric pocket in the TMD and activate the receptor
Rare but serious: Pancreatitis, gallbladder disease, and a theoretical risk of thyroid C-cell tumors based on animal studies
