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A comprehensive physical examination and detailed medical history should be performed to identify these individuals

The deficiency of B cell adapter for PI3K (BCAP) down-regulated the glycolytic enzyme phosphofructokinase-3 (PFKFB3) and mTORC1 signaling, which attenuated aerobic glycolysis and l-lactate production, further decreasing histone l-lactylation of reparative genes in macrophages

It theoretically combines the advantages of both tirzepatide and survodutide