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Choose varied injection sites (abdomen, upper arm, or thigh) in rotating locations to prevent lipodystrophy, a condition where repeated injections in the same spot cause tissue changes

Thats because obesity is a chronic disease, Dr

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Longer Duration of Action Structural modifications help tirzepatide remain active for extended periods, supporting convenient once-weekly dosing

Change history 25 March 2026 A Correction to this paper has been published: Abbreviations AOM: Anti-obesity medication WMD: Weighted mean difference CI: Confidence interval SD: Standard deviation RCT: Randomized controlled trial GLP-1 RA: Glucagon-like peptide 1 receptor agonist GIP: Glucose-dependent insulinotropic polypeptide GCCR: Glucagon receptor BMI: Body mass index References World Obesity Federation

This can depend on various factors, including your starting weight and how closely you adhere to the nutrition plan