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These insulin-sensitizing effects of LXR repression may offer additional cardioprotective benefit to that attributable to improvements in circulating lipids 56
Abstract Nutraceuticals-including resveratrol (RSV), curcumin (CUR), piperine (PPR), and quercetin (QUE)-exhibit dual therapeutic and toxicological profiles, are necessitating balanced riskbenefit evaluation
The OPTION-DM trial was a multicenter, randomized, crossover study comparing three monotherapy sequences (amitriptyline, duloxetine, pregabalin) against two dual-therapy sequences in patients who had failed one monotherapy [65]
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To date, liraglutide, and the more effective once-weekly semaglutide, have been approved in the US and Europe for the treatment of obesity, with unprecedented weight loss of up to 1520%
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