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Description

Dihexa binds to hepatocyte growth factor (HGF) with high affinity ( K d =65 pM) and potentiates its activity at its receptor, c-Met

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Another study reported that injection of the GLP-1 agonist exendin-4 influenced the dopamine system and reduced food-related reward behavior in rats (Hayes and Schmidt, 2016)

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Major TJ, Topless RK, Dalbeth N, Merriman TR

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At the molecular level, the mechanism has been structurally resolved by NMR spectroscopy (Nature Communications, 2025): FOXO4-DRI binds to the disordered p53 TAD2 domain and forms a transiently folded complex through both the FOXO4-derived peptide region and its cationic cell permeability element

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