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doi: 10.1039/C8FO02301H 87 LeyerGJLiSMubasherMEReiferCOuwehandAC

Combined 5-MTHF + methylcobalamin support is the standard nutritional intervention for MTHFR T/T-associated functional folate insufficiency

Storage Store in a cold, dry place away from heat sources

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Patients need to be committed to the process and have realistic expectations

The synergy might arise from the combined action of GHK-Cu in stimulating glycosaminoglycan production, promoting collagen synthesis, and HA's role in reducing collagen degradation by scavenging reactive oxygen species and inhibiting matrix metalloproteinases