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The ongoing clinical studies aim to provide robust clinical evidence for their efficacy in cognitive enhancement and disease modification in Alzheimers and related disorders
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Multiple sequence alignment analyses revealed that GSTO1-1 and GSTO2-2 contain a conserved catalytic cysteine residue and GSH binding sites, while other classes of GSTs have different amino acids in these positions, explaining why only GSTOs show DHAR activity 10,13
Earlier-stage research and a narrower use case
2019 Sep Bernard Schmitt, Morgane Vicenzi, Catherine Garrel, Frdric M Denis
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