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Copper (Cu) is essential for the activation of superoxide dismutase (SOD, antioxidant defense), lysyl oxidase (collagen cross-linking), and wound-healing enzymes
Proc Natl Acad Sci 91(1):210214 Zheng Y, Cantley LC (2019) Toward a better understanding of folate metabolism in health and disease
Glutathione peroxidase 4 (GPx4) has a high preference for lipid hydroperoxides
When this happens, the vagina may also get drier because it loses its natural moisture
Under cystine deprivation, mTORC1 activity is inhibited, leading to reduced GPX4 protein levels and thereby enhancing cellular sensitivity to ferroptosis (71)
Klin Onkol 25(Suppl 2):2S872S92 Nicolas CS, Amici M, Bortolotto ZA, Doherty A, Csaba Z, Fafouri A, Dournaud P, Gressens P, Collingridge GL, Peineau S (2013) The role of JAK-STAT signaling within the CNS
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