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(FYI, participants were not on any other diabetes medications at the start of the trial.) Participants also had an average weight loss of 4.5%7.6% over the same period, with those who took higher doses experiencing the higher end of the range of weight loss

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If GLP-1 therapy turns down one volume knob on the brains hunger signal, cagrilintide turns down a different, parallel volume knob

Exendin-4, which shows 53% structural homology with GLP-1 (7-36), is as potent as endogenous GLP-1 in its insulinotropic effects via the mammalian GLP-1R