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Evidence quality remains limited, and results vary significantly between individuals

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When used in conjunction with diet and exercise, it can cause significant weight loss and a reduced risk of cancer, diabetes and heart disease in people who are obese or overweight

Chronobiology of Melatonin beyond the Feedback to the Suprachiasmatic Nucleus-Consequences to Melatonin Dysfunction

The same concerns that apply to questions about peptide expiration apply here