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ISSN 0002-7863

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Moreover, as mitochondria play a central strategic role in the activation and mode of cell death, mitochondrial GSH has been shown to critically regulate the level of sensitization to secondary hits that induce mitochondrial membrane permeabilization and release of proteins confined in the intermembrane space that once in the cytosol engage the molecular machinery of cell death

The process of recycling oxidized glutathione back into the reduced form requires energy and specific co-factors like NADPH

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Treating them the same is the most common mistake we see