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The oxidation of the dihydrolipoyl moiety is catalyzed by a dihydrolipoamide dehydrogenase ( Figure 2 )
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Postmortem studies have revealed evidence for oxidative injury in PD brains, demonstrating lipid peroxidation and oxidative modification of proteins and DNA 6
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If you are homozygous (677T/T or 1298C/C) your enzyme efficiency can drop as low as 20% of normal
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