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There are two 2HG enantiomers: D-2-hydroxyglutarate (D2HG) and L-2-hydroxyglutarate (L2HG), with the former predominantly generated from IDH1 mutants and PHGDH while L2HG is primarily generated from the promiscuous activity of LDHA and MDH1/2 under hypoxic or acidic conditions and converted back to 2OG by L2HGDH

BPC-157 may act upstream, downstream, or in parallel with NO-dependent pathways

doi:10.1186/1750-1172-5-39 5Coleman EL, Olamiju B, Leventhal JS

More specifically, the superior mesenteric vein, inferior and superior anterior pancreaticoduodenal, pyloric vein, and portal vein in the superior mesenteric vein-portal vein shunt reestablish the interrupted superior mesenteric and portal vein pathway (the occluded end of the superior mesenteric vein) (Vukojevic et al., 2018

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J Biol Chem 280 , 3376633774, doi: 10.1074/jbc.M504604200 (2005)