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\Cardiovascular Protection: 50% reduction in cardiovascular mortality over 12 years (Human Study)

It is difficult to consider some confounders (such as dosage, duration of use, comorbidities, and drug combinations) that may influence the occurrence of gastrointestinal toxicity

these factors may contribute to a higher incidence of hepatobiliary adverse events [2,37]

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For example, the acute stress response in Atlantic cod ( Gadus morhua ) is generally less severe than in salmonids where impacts on intestinal integrity is less noticeable with lower magnitude of cortisol and glucose changes and lower increase in clinical markers for tissue damage (Olsen et al., 2008)