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It raises energy expenditure, meaning your body burns more calories even at rest

Studies enrolling patients with severe obesity (BMI 40) may not generalize perfectly to broader populations

First-pass metabolism: Anything that survives the gut must pass through the liver, where it may be further processed before reaching the rest of the body

It took the brand manufacturers more than two years to build enough capacity for the FDA to declare the shortages over, which happened on December 19, 2024, for Eli Lillys tirzepatide products, and February 21, 2025, for Novo Nordisks semaglutide products