For ongoing care, especially if you have a chronic condition causing the deficiency, you might need maintenance shots, maybe every two months or even monthly
A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)
Rarely, patients report mild digestive upset or headache
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