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However, in contrast to anti-hyperlycemic agents such as metformin, pioglitazone and peroxisome proliferator-activated receptor gamma (PPAR) agonists, which were particularly well studied in this matter, very few clinical studies concerning the effects of GLP-1R targeting therapeutics on alleviation of depressive symptoms in humans have been carried out so far [118, 119]

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While earlier trials did not have dedicated RCTs at their disposal, studies such as the SOUL trial had 3 prior RCTs to refer to, as far as baseline CV risk estimation was concerned

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