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Abstract Purpose of Review To review carnitines role in migraine and headache, present a case of a patient with intractable chronic migraine refractory to medications but exquisitely responsive to mitochondrial cofactors with a particularly prompt response to L-carnitine supplementation with dose response, and suggest scenarios where L-carnitine could be considered for prophylactic treatment in migraine and intractable headache with migraine features

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JSTOR 3870806

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Thus, ChaC2 serves as a constitutively expressed protein for basal hydrolysis of GSH, acting as a steward for slow and continuous GSH turnover (47)