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mTOR binds to the lysosomal membrane during normal caloric intake and phosphorylates the transcription factor EB (TFEB), which regulates the genes involved in autophagy, as well as those encoding lysosomal components and peroxisome proliferator-associated receptor (PPAR)- and - (79)
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As previously discussed, the addition of the C-terminal hydrophobic residues isoleucine and alanine in A 142 favors oligomerization into the hexameric barrel shape and thus would increase both its antimicrobial and cytotoxic potential (Lendel et al., 2014