glp-1 and serotonin Acute GLP-1R activation alters turnover serotonin Nutrient-induced glucagon like peptide-1 release

Volunteers were randomized to either receive a placebo or one of three varying doses of orforglipron, taken once a day (as is common with GLP-1 therapy, people gradually reached their maximum dose over time)

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For patients with food addiction features, this neurologic effect may be the most powerful aspect of therapy

11 John Cronin, MD, senior vice president of clinical development at Apnimed, underscores the need for diverse treatment options

Longato E, Di Camillo B, Sparacino G, Tramontan L, Avogaro A, Fadini GP