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It has been shown that exendin-4 reduces mitochondrial toxicity in an A-induced AD mouse model, an effect that was mediated through PI3K/protein kinase B (Akt) signaling [53]

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Members of this group include the XMAP215 family of microtubule polymerases that promote microtubule growth by binding to plus ends and increasing the rate of tubulin addition by recruiting tubulin dimers [4, 39]

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Harmonic restraints of 50.0 kcal mol 1 2 were applied to the solutes, including the crystallographic ions, to allow solvent relaxation while preserving the maximum fidelity to the docking pose, and the Andersen temperature coupling scheme 81,82 was used to control and equalize the temperature