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GLP-1s: Effective Preventive Treatment for Chronic Diseases Chronic diseases such as diabetes, cardiovascular disease, CKD, and obesity have long been significant drivers of healthcare costs in the US
Jul 1 2020;112(1):74-83
Foods and/or Food Components that May Harm Brain Function Alcohol Description: Wine Beer Spirits Potential Mechanism(s): Neurotoxic effects 271 Scientific Evidence: Study 1 Study Design: Meta-analysis of multiple controlled trials Results: Alcohol has a short-term negative impact on working memory function in healthy adults 272 Study 2 Study Design: Observational/Correlational Subjects: 2,416 adults Results: Light-to-moderate alcohol consumption in mid-life was not associated with cognitive function later in life 273 Study 3 Study Design: Observational/Correlational Subjects: 36,678 healthy middle-aged and older adults Results: Moderate alcohol consumption was correlated with negative changes in brain structure, with diminished total brain and brain cell (gray matter) volumes, and damage to interconnecting nerve fibers (white matter) 274 Study 4 Study Design: Observational/Correlational Subjects: 20,729 participants Results: Moderate alcohol use associated with increased iron accumulation in brain tissue
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95% CI 0.94, 1.03)
Western Blotting The protein levels of dynamin-related protein (Drp)-1, fission protein (Fis)-1, phosphatase and tensin homolog induced putative kinase (Pink)-1, Parkin, optic atrophy (Opa)-1, light chain 3 microtubule-associated protein A/B (LC3A/B), manganese superoxide dismutase (MnSOD), translocase of outer membrane (Tom)-20 and OXPHOS complexes were measured by western blotting
