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Patients should not use tirzepatide if the solution exhibits: Pink, red, or brown coloration throughout the solution Cloudiness, haziness, or loss of clarity Visible particles, crystals, or floating material Discoloration present in an unopened, unused auto-injector Any appearance that is not clear and colorless to slightly yellow These findings suggest chemical degradation, contamination, or product defect that may compromise both safety and efficacy

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Indirect network meta-analyses rank retatrutide highly, but that is cross-trial inference, not a direct win