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This tolerability gap may shrink with the optimized titration schedules being tested in Phase 3, but it represents a real limitation of the current Phase 2 protocol

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nausea-related fasting may compound this Weight-loss overlap / both agents reduce appetite through distinct mechanisms Blood glucose monitoring / recommended if patient has type 2 diabetes on liraglutide Dose adjustment required / none for either drug based on current evidence Why This Combination Comes Up in Practice Liraglutide (marketed as Victoza for type 2 diabetes and Saxenda for chronic weight management) and bupropion (marketed as Wellbutrin for depression and as a component of Contrave for obesity) are both prescribed in populations seeking weight reduction or metabolic improvement

Average weight gain is about 5-7 pounds over 1-2 years, with some patients gaining substantially more