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The intranasal delivery route enabled direct brain access via olfactory and trigeminal pathways, bypassing the blood-brain barrier while maintaining low systemic copper levels to minimize toxicity risk

Autophagy 19 , 616631 (2023)

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This therapy is ideal for individuals with osteoarthritis or musculoskeletal injuries who cannot tolerate corticosteroid injections, have contraindications to steroids, or have not experienced relief from prior steroid or viscosupplementation treatments